Publications

Changes in neurotensin signalling drive hedonic devaluation in obesity

Gazit Shimoni N, Tose AJ, Seng C, Jin Y, Lukacsovich T, Yang H, Verharen JPH, Liu C, Tanios M, Hu E, Read J, Tang LW, Lim BK, Tian L, Földy S, Lammel S (2025). Nature

Dopamine D1 receptor activation in the striatum is sufficient to drive reinforcement of anteceding cortical patterns

Vendrell-Llopis N, Read J, Boggiano S, Hetzler B, Peitsinis Z, Stanley C, Visel M, Trauner D, Donthamsetti P, Carmena C, Lammel S, Isacoff EY (2025). Neuron 113, 1–10

State and rate-of-change encoding in parallel mesoaccumbal dopamine pathways

de Jong JW, Liang Y, Verharen JPH, Fraser KM, Lammel S (2024). Nature Neuroscience 27, 309-318

Head-mounted central venous access during optical recordings and manipulations of neural activity in mice

Liu C, Freeman DJ, Lammel S (2023). Nature Protocols 19, 960-983

Dopamine release and negative valence gated by inhibitory neurons in the laterodorsal tegmental nucleus

Du Y, Zhou S, Ma C, Chen H, Du A, Deng G, Liu Y, Tose AJ, Sun L, Liu Y, Wu H, Lou H, Yu Y, Zhao T, Lammel S, Duan S, Yang H (2023). Neuron 111, 3102-3118.e7

A computational analysis of mouse behavior in the sucrose preference test

Verharen JPH, de Jong JW, Zhu Y, Lammel S (2023). Nature Communications 14, 2419

An inhibitory brainstem input to dopamine neurons encodes nicotine aversion

Liu C, Tose AJ, Verharen JPH, Zhu Y, Tang LW, de Jong JW, Du JX, Beier KT, Lammel S (2022). Neuron 110, 3018-3035.e7

Transient food insecurity during the juvenile-adolescent period affects adult weight, cognitive flexibility, and dopamine neurobiology

Lin WC, Liu C, Kosillo P, Tai LH, Galarce E, Bateup HS, Lammel S, Wilbrecht L (2022). Current Biology 32, 3690-3703.e5

Mesoaccumbal Dopamine Heterogeneity: What Do Dopamine Firing and Release Have to Do with It?

de Jong JW, Fraser KM, Lammel S (2022). Annual Review of Neuroscience 45, 109-129

Pain modulates dopamine neurons via a spinal–parabrachial–mesencephalic circuit

Yang H, de Jong JW, Cerniauskas I, Peck JR, Lim BK, Gong H, Fields HL, Lammel S (2021). Nature Neuroscience 24, 1402-1413

Cell specific photoswitchable agonist for reversible control of endogenous dopamine receptors

Donthamsetti P, Winter N, Hoagland A, Stanley C, Visel M, Lammel S, Trauner D, Isacoff E (2021). Nature Communications 12, 4775

Relocation of an Extrasynaptic GABAA Receptor to Inhibitory Synapses Freezes Excitatory Synaptic Strength and Preserves Memory

Davenport CM, Rajappa R, Katchan L, Taylor CR, Tsai, M, Smith CM, de Jong JW, Arnold DB, Lammel S, Kramer RH (2021). Neuron 109, 123-134

Dopaminergic Control over the Tripartite Synapse

Verharen JPH, de Jong JW, Lammel S (2020). Neuron 105, 954-956

Aversion hot spots in the dopamine system

Verharen JPH, Zhu Y, Lammel S (2020). Current Opinion in Neurobiology 64, 46-52

Chronic stress induces activity, synaptic and transcriptional remodeling of the lateral habenula associated with deficits in motivated behaviors

Cerniauskas I, Winterer W, de Jong JW, Lukacsovich D, Yang H, Khan F, Peck JR, Obayashi SK, Lilascharoen V, Lim BK, Földy C, Lammel S
(2019). Neuron 104, 1-17

Characterization of transgenic mouse models targeting neuromodulatory systems reveals organizational principles of the dorsal raphe

Cardozo Pinto DF, Yang H, Pollak Dorocic I, de Jong JW, Han VJ, Peck JR, Zhu Y, Liu C, Beier KT, Smidt MP, Lammel S (2019). Nature Communications 10: 4633

Hot topic in optogenetics: new implications of in vivo tissue heating

Cardozo Pinto DF, Lammel S (2019). Nature Neuroscience 22, 1039-1041

A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System

de Jong JW, Afjei SA, Pollak Dorocic I, Peck JR, Liu C, Kim CK, Tian L, Deisseroth K, Lammel S (2019). Neuron 101, 1-19

Nucleus Accumbens Subnuclei Regulate Motivated Behavior via Direct Inhibition and Disinhibition of VTA Dopamine Subpopulations

Yang H, de Jong JW, Tak Y, Peck J, Bateup HS, Lammel S (2018). Neuron 97, 1-16

Viral vector strategies for investigating midbrain dopamine circuits underlying motivated behaviors

Cardozo Pinto DF, Lammel S (2018). Pharmacol. Biochem. Behav. pii: S0091-3057(16)30318-5

Optogenetic Approaches to Neural Circuit Analysis in the Mammalian Brain

Lammel S, Dölen G, Malenka RC (2016). Genomics, Circuits, and Pathways in Clinical Neuropsychiatry Elsevier, Inc. ISBN: 9780128001059

Diversity of transgenic mouse models for selective targeting of midbrain dopamine neurons

Lammel S*, Steinberg EE*, Földy C*, Wall NR, Beier K, Luo L, Malenka RC (2015). Neuron 85, 429-438

Natural neural projection dynamics underlying social behavior

Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A, Lammel S, Mirzabekov JJ, Airan RD, Zalocusky KA, Tye KM, Anikeeva P, Malenka RC, Deisseroth K (2014). Cell 157, 1535–155

Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons

Dragicevic E, Poetschke C, Duda J, Schlaudraff F, Lammel S, Schiemann J, Fauler M, Hetzel A, Watanabe M, Lujan R, Malenka RC, Striessnig J, Liss B (2014). Brain 137, 2287–2302

Progress in understanding mood disorders: optogenetic dissection of neural circuits

Lammel S, Tye KM, Warden MR (2014). Genes Brain Behavior 13, 38-51

Reward and aversion in a heterogeneous midbrain dopamine system

Lammel S*, Lim BK*, Malenka RC (2014). Neuropharmacology 76 Pt B, 351–359

New Insights into the Specificity and Plasticity of Reward and Aversion Encoding in the Mesolimbic System

Volman SF, Lammel S, Margolis EB, Kim Y, Richard JM, Roitman MF, Lobo MK (2013). Journal of Neuroscience 33, 17569-17576

Illuminating the opponent process: cocaine effects on habenulomesencephalic circuitry

Rothwell PE, Lammel S (2013). Journal of Neuroscience 33, 13935-13937

Input-specific control of reward and aversion in the ventral tegmental area

Lammel S*, Lim BK*, Ran C, Huang KW, Betley MJ, Tye K, Deisseroth K, Malenka RC (2012). Nature 491, 212-217

Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli

Lammel S, Ion DI, Roeper J, Malenka RC (2011). Neuron 70, 855-862

Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system

Lammel S, Hetzel A, Häckel O, Jones I, Liss B, Roeper J (2008). Neuron 57, 760-73