Check out our video panel discussion in which Stephan Lammel, Karel Svoboda, and David Kupferschmidt answer questions about the caveats and limitations of optogenetics. Topics include assessing potential channelrhodopsin induced toxicity, determining direct versus circuit effects of optogenetic manipulation, reliability of wireless optogenetic hardware, and others.
https://neuronline.sfn.org/Articles/OTS/Module-8/Caveats-and-Limitations-of-Optogenetics